Intern - Computational Biology For Antibody Design (M/F/D)

Job Description

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

We are seeking an intern preferably pursuing M.Sc. degree program with experience in computational structural biology and/or machine learning. You will join the “birthplace” of therapeutic proteins in Roche’s discovery unit and work on the development of novel machine-learning-based approaches for antibody design.

The objective of this project is to generate antibodies with desired binding properties. Thus, you will be analyzing public and in-house structural data to identify characteristics of protein and antibody interactions. You will then apply these learnings to develop machine learning methods to generate antibodies with the desired properties. Different machine learning models will be applied for this project, tailored to the purpose (i.e., structural-aware version of GNNs).

This project plays a role in significantly accelerating the design of therapeutic antibodies. You will have the opportunity to disseminate your findings to our cross-functional project teams, contributing to Roche’s innovative research efforts.

We are looking for individuals who are:

• Creative problem solvers, quick learners, and comfortable experimenting with new approaches

• Highly productive and enjoy dealing with ambiguity and applying novel methodologies

Responsibilities:

• Collaborate with the host team to evaluate potential antibody design techniques and applications

• Develop and interpret machine learning algorithms to address selected research questions, including model selection and data preparation

• Proactively share learnings and knowledge to support the development of the wider Roche computational community

• Help shape the direction of machine learning and artificial intelligence within Roche

Preferred Experience and Competencies:

• Knowledge of software development and fluency in Python

• Understanding of machine learning frameworks (e.g., PyTorch, Jax, TensorFlow)

• Experience with antibody informatics, protein structural modeling, and protein-protein interaction characterization. Experience in protein surface representations and PDB mining is a plus

• Familiarity with technologies required to undertake analyses on large data sources or with computationally intensive steps (Linux, HPC cluster computing)

• Strong communication and collaboration skills

• Experience implementing reproducible research practices like version control (e.g., using Git) is a plus

Qualifications Required:

• Preferably M.Sc. degree candidate in Bioinformatics, Statistics, Biomedical Engineering, Computer Science, or a related field with a Biology background

• You are proficient in English and not afraid of talking to international clients

Your Advantages:

• Flexible time management

• 2025 € salary per month for a full-time internship > 3 months

• Reduced meal prices (-50%) in our employee canteen

• Fitness center on the Roche campus

• Networking with other students

• The possibility of accommodation in the Roche Boarding House or convenient transport connections to Munich with the Roche Shuttle

Your Application

Please upload your Curriculum vitae specific to this position.

Keep in mind that this internship is only directed at students (m/f/d) who are currently enrolled at university or are in their Gap year (between Bachelor's and Master's studies).

Start

As of mid-September or according to agreement for a period of 6 months

We are excited to see your application!

Do you need further support?

Please have a look at our FAQs, you will find them via https://careers.roche.com/global/en/faq.

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche at Penzberg, near Munich, employs more than 7,000 people. The site is one of the largest biotechnology centers in Europe and the only Roche site with research, development and production for both Pharmaceuticals and Diagnostics under one roof. From your beginning with Roche, our motivated team will welcome and support you. Numerous opportunities for personal development, flexible work hours, attractive compensation packages and special family assistance programs are available.

Roche is an Equal Opportunity Employer.