Phd Project: Role Of Catecholamines In Neuroimmune Communication And Inflammation In Cardiovascular & Infectious Diseases (M/W/D)

Campus Großhadern

Full time

Medizinische Klinik I (Kardiologie)

Cardiology, basic and translational research

At the earliest possible date

01.08.2025

2025-K-0236

• In this project, we investigate how neuroendocrine mediators—especially catecholamines—shape the innate immune response during inflammation.
• Our focus is to unravel the molecular mechanisms that govern neuroimmune interactions, particularly in the context of cardiovascular disease and bacterial infections.
• Stress has been linked to the development and progression of many inflammatory diseases, including cardiovascular diseases and sepsis.
• Through activation of the HPA axis and sympathetic nervous system, stress drives the release of catecholamines, which can profoundly influence immune responses.
• This project explores how these stress hormones modulate inflammatory processes across various models.
• By combining expertise in in vitro approaches, murine models, and translational research, we aim to uncover how catecholamines regulate the innate immune response during inflammation.
• We will identify key molecular pathways influenced by catecholamines under both physiological and inflammatory conditions.
• Our experimental designs will allow mechanistic validation of candidate pathways involved in cardiovascular and bacterial inflammation.
• We will extend our findings to translational studies in patients receiving catecholamine therapy.
• Ultimately, we want to define novel targets for therapeutic intervention in stress-associated inflammatory and cardiovascular diseases.

• State-of-the-art facilities: Access to modern laboratory infrastructure, advanced imaging platforms, flow cytometry, genomics, and animal research facilities.
• Comprehensive training and mentorship: Receive close scientific supervision and mentorship from experienced researchers, along with tailored training in experimental techniques, data analysis, and scientific communication. Acquire comprehensive background knowledge on the pathogenesis of stress-associated diseases and establish expertise in murine models for experimental research (e.g., through TVK or FELASA-certified laboratory animal science training).
• Career development opportunities: Participate in workshops, conferences, and seminars designed to strengthen your professional and academic skills.
• International and collaborative atmosphere: Work in a highly collaborative and international environment, with opportunities to engage in joint projects.
• Impactful research: Perform translational research, including studies in a clinical setting at a renowned hospital involving patients undergoing catecholamine therapy, to enhance the clinical relevance of experimental findings.
• Performance-based salary: The remuneration is based on the Collective Agreement for the Public Service of the Federal States (TV-L), plus all customary allowances typical for the public sector.